CAS:150417-90-6丨GC7Sulfate
Molecular Formula: C8H22N4O4S
Molecular Weight: 270.35
Purity: 98%
Package:0.1g 0.25g 1g 5g 10g 25g
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Products Description
ThetreatmentofMYCN2(±Dox)andBE(2)-CcellswithGC7Sulfatefor72hatvariousconcentrations(0.1to100μM)significantlyreducesthenumberofviablecellsinadose-dependentmanner.InMYCN2cells,5μMofGC7Sulfateinhibitscellviabilityby~40and~60%,respectively,comparetountreatedcontrolcells.BE(2)-Ccellsrequire25μMofGC7Sulfatetoreducecellviabilityby~50%.Exposureto10and100μMGC7for72hclearlydecreasesthelevelsoftotalretinoblastoma(Rb)andphosphorylatedRbaswellasofCdk4prChemicalbookotein,andincreasesthelevelsofp21protein.Between0and20μM,GC7SulfateinduceslittlecytotoxicityinHCCcells,whilehigherconcentrationsofGC7Sulfate(50to100μM)significantlyinhibittheviabilityofallfiveHCCcelllinestested.Newlysynthesized3H-labeledhypusineofeIF5A1/eIF5A2israrelydetectedafter20μMGC7Sulfatetreatment,comparetountreatedcontrol.Theactivityof[3H]-spermidineincorporatedintoHCCcellsissignificantlydecreasedby20μMGC7Sulfateorhigherconcentration.
CAS:150417-90-6
Specification
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ITEMS |
SPECIFICATION |
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CAS |
150417-90-6 |
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Purity |
98% |
Populární Tagy: cas:150417-90-6丨gc7sulfate, price, quotation, discount, in stock, for sale
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